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Lung cancer is the most common epithelial tumor and the leading cause of cancer death worldwide. This, together with the lack of LSCC-specific therapeutic targets, has resulted in few recent significant advances in the treatment of this disease Liao et al. Consequently, despite its limited effectiveness on disease progression and prognosis, platinum-based chemotherapy remains the cornerstone of current treatment for LSCC Scagliotti et al. Therefore, elucidating the critical molecular pathways Dg gentlemen club Askoy in LSCC is crucial to identify new therapeutic approaches. In physiological conditions, this pathway is tightly regulated by ubiquitylation.

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The increase in linear ubiquitylation was not due to an overall change in Swingers heaven Porsgrunn ubiquitin species or seen with other ubiquitin chain topologies Fig. Consequently, despite its limited effectiveness on disease progression and prognosis, patients with LSCC receive the same conventional platinum-based chemotherapy today as they Askou have received two decades ago Scagliotti et al.

LUBAC determines chemotherapy resistance in squamous cell lung cancer

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Ruiz, M. The authors declare no competing financial interests. In physiological conditions, this pathway is tightly regulated by ubiquitylation.

Munib Mesinovic. Cancer Discov.

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Statistical analysis was performed using GraphPad Prism software. Care Med.

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